Tim Bastian Schille
Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI)
Microbial Pathogenicity Mechanisms
The Candida albicans peptide toxin candidalysin as a commensal factor facilitating mucosal colonization
Candida albicans is one of the most common fungal pathogens of humans. Mucosal surfaces of most humans (> 70%) are colonized by this fungus without causing harm. However, under certain circumstances this commensal can cause moderate to severe disease.
PhD start: 01/15/2023
Supervisors
Prof. Dr. Bernhard Hube
Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI)
Microbial Pathogenicity Mechanisms
Publications
Sprague JL, Schille TB, Allert S, Trümper V, Lier A, Großmann P, Priest EL, Tsavou A, Panagiotou G, Naglik JR, Wilson D, Schäuble S, Kasper L, Hube B2024Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection. PLoS Pathog 20, e1012031.
Funded by
