Synthesis and application of covalent inhibitors targeting microbial enzymes

Activity-based protein profiling (ABPP) is an innovative chemoproteomic method that enables the selective labeling and characterization of active enzymes in complex biological systems. ABPP uses chemical probes which carry a reactive group (“warhead”) that covalently binds to the active site of enzymes, allowing their visualization through conjugated fluorophores or their identification via mass spectrometry. The Lakemeyer research group has recently developed a novel class of probes that exhibit promising antifungal properties, especially against human pathogens. The aim of the doctoral project is to develop inhibitors and chemical probes with improved potency and stability, and to elucidate their exact antifungal mode of action.

PhD start: 05/05/2025