Dr. rer. nat. Jakob Lee Sprague
Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI)
Microbial Pathogenicity Mechanisms
Additional research training group: FungiNet
Molecular characterization of Candida albicans mucosal colonization, infection and translocation
PhD start: 04/01/2019
Supervisors
Prof. Dr. Bernhard Hube
Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI)
Microbial Pathogenicity Mechanisms
Publications
Alonso-Roman R, Last A, Mirhakkak MH, Sprague JL, Möller L, Großmann P, Graf K, Gratz R, Mogavero S, Vylkova S, Panagiotou G, Schäuble S, Hube B, Gresnigt MS2022Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity. Nat Commun 13, 3192-3192.
Sprague JL, Schille TB, Allert S, Trümper V, Lier A, Großmann P, Priest EL, Tsavou A, Panagiotou G, Naglik JR, Wilson D, Schäuble S, Kasper L, Hube B2024Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection. PLoS Pathog 20, e1012031.
Sprague JL, Kasper L, Hube B2022From intestinal colonization to systemic infections: Candida albicans translocation and dissemination. Gut Microbes 14, 2154548.
Funded by
