Spatio-temporal modelling of biological systems

Macromolecular crowding is a key feature of biological systems that influences molecular diffusion, reaction kinetics, and cellular behavior from intracellular environments to microbial biofilms. This project aims to investigate how crowding affects reaction–diffusion processes, with particular emphasis on enzymatic reactions and pathogen responses to antimicrobial compounds. We develop computational models that incorporate crowding-dependent transport and reaction kinetics to study how molecular size, spatial organization, and local environmental changes modulate biochemical processes. The project will provide new insights into microbial survival strategies, biofilm dynamics, and the effectiveness of antimicrobial treatments.

PhD start: 05/01/2025