Natural Products from Social Amoebae.
Barnett R, Stallforth P2018Natural Products from Social Amoebae. Chemistry 24, 4202-4214.
Abstract
Natural products are invaluable sources of structural diversity and complexity ideally suited for the development of therapeutic agents. The search for novel bioactive molecules has prompted scientists to explore various ecological niches. Microorganisms have been shown to constitute such an important source. Despite their biosynthetic potential, social amoebae, that is, microorganisms with both a uni- and multicellular lifestyle, are underexplored regarding their secreted secondary metabolome. In this review, we present the structural diversity of amoebal natural products and discuss their biological functions as well as their total syntheses.
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Doctoral researchers
Robert Barnett
Discovery of Small Molecule Inhibitors of Multicellular Development
Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI)
Paleobiotechnology