Candida Species-Dependent Release of IL-12 by Dendritic Cells Induces Different Levels of NK Cell Stimulation.

Marolda A, Hünniger K, Böttcher S, Vivas W, Löffler J, Figge MT, Kurzai O 2020 Candida Species-Dependent Release of IL-12 by Dendritic Cells Induces Different Levels of NK Cell Stimulation. J Infect Dis 221, 2060-2071.

Abstract

Candida albicans and Candida glabrata are the 2 most prevalent Candida species causing bloodstream infections. Patterns of innate immune activation triggered by the 2 fungi differ considerably.

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Doctoral researchers

Dr. rer. nat. Alessandra Marolda

Dr. rer. nat. Alessandra Marolda

Characterizing innate immune cell activation by fungal pathogens using Live Cell Imaging

Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI)

Applied Systems Biology

Dr. rer. nat. Wolfgang Vivas

Dr. rer. nat. Wolfgang Vivas

Modulation of Dendritic Cell Function by the fungal Quorum Sensing Molecule Farnesol