Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota.
Gressler M, Löhr NA, Schäfer T, Lawrinowitz S, Seibold PS, Hoffmeister D2021Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota. Nat Prod Rep 38, 702-722.
Abstract
Covering: up to September 2020 Mushroom-forming fungi of the division Basidiomycota have traditionally been recognised as prolific producers of structurally diverse and often bioactive secondary metabolites, using the methods of chemistry for research. Over the past decade, -omics technologies were applied on these fungi, and sophisticated heterologous gene expression platforms emerged, which have boosted research into the genetic and biochemical basis of the biosyntheses. This review provides an overview on experimentally confirmed natural product biosyntheses of basidiomycete polyketides, amino acid-derived products, terpenoids, and volatiles. We also present challenges and solutions particular to natural product research with these fungi. 222 references are cited.
Links
Doctoral researchers
Stefanie Lawrinowitz (neé Scheide)
stefanie.lawrinowitz@uni-jena.de
Secondary metabolome dynamics in structured artificial microhabitats
Friedrich Schiller University
Pharmaceutical Microbiology
Paula Seibold
Stimulation of basidiomycete indoleethylamine metabolism by spatiotemporal light and temperature gradients
Friedrich Schiller University
Pharmaceutical Microbiology