Projects offered within the Recruitment Call 2021/01

We are curently offering two doctoral researcher positions and a postdoctoral researcher position. We are seeking motivated and engaging candidates who strive to collaborate widely and look beyond traditional disciplines to further our mission.

Application deadline: 29th April 2021

Applications for these positions are accepted via the JSMC Online Application Portal: apply.jsmc.uni-jena.de

Microbiota-driven risk assessment, prevention and clearance of invasive aspergillosis

Microverse Doctoral Researcher Project No: 05/2021

The research objectives of this project are: (1) to investigate the dysbalance in gut and lung microbiota associated with the immunosuppression and pathogenesis of A. fumigatus, (2) to identify microbiome-related metabolic dependencies of A. fumigatus pathogenesis that can be used to explore novel drugable targets, (3) to interrogate whether the therapeutic benefit of antifungal treatment is in part mediated by the gut and lung microbiota or whether antifungal treatment helps to rebalance the distorted microbiome.

PhD Supervisor: Prof. Dr. Axel Brakhage

The role of CD4+ Foxp3+ regulatory T cells for gut microbiome constitution: atherosclerosis and modulatory effects of physical exercise

Microverse Doctoral Researcher Project No: 08/2021

Our laboratory is interested in the balance and dysbiosis of the gut microbiome and the possibility to treat our patients by rebalancing their gut microbiome to a healthy state. We aim to assess the influence of exercise on Tregs, the gut microbiome and the resulting atherosclerotic process. Little is known about the molecules produced by microorganisms to activate Tregs, how Tregs structure the microbiome and how changes in the microbiome lead to atherosclerosis development, specifically in light of the role of Tregs.

Supervisor: Dr. Thierry Siemeni

T-Cell Immunology

HKI Doctoral Researcher Project No: 49/2021

The Department of Infection Immunology addresses fundamental questions about the mechanistic basis of human T-cell memory formation, stabilization, and modulation. It also investigates T-cell communication with the local tissue microenvironment in settings of infections, autoimmunity and cancer. This research has unraveled several novel T-cell functions and immunomodulatory factors. The department uses novel cutting-edge technologies in the area of high-dimensional single-cell analysis (scRNAseq, Spectral flow cytometry) to translate fundamental insights into translational applications for human health and disease. The prospective candidate will have the opportunity to investigate the metabolic regulation of human tissue resident T-cells and their crosstalk with the microenvironment.

Supervisor: Prof. Dr. Christina Zielinski

Consequences of bacterial-fungal interactions for intestinal colonization and development of the immune system

Microverse Postdoctoral Researcher Project No: 07/2021

The aim of this project is to gain novel insights into microbial interactions in the gut and the consequences for microbial colonization and host responses by using three model microbes: C. albicans, Bacteroides vulgatus, and E. faecalis.

Supervisor: Prof. Dr. Ilse Jacobsen